The cellular prion protein PrP is a partner of the Wnt pathway in intestinal epithelial cells
نویسندگان
چکیده
*Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France; †INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France; ‡Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France; §Institut Curie, PSL Research University, Centre de Recherche, F-75005, Paris, France; ||CNRS/UMR144, F-75005, Paris, France; ¶Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie, Pavillon Pasteur, Paris, F-75248 France; @Ecole Pratique des Hautes Etudes, F75014, Paris, France. #Caroline Clair in memoriam
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The cellular prion protein PrPc is a partner of the Wnt pathway in intestinal epithelial cells
We reported previously that the cellular prion protein (PrP(c)) is a component of desmosomes and contributes to the intestinal barrier function. We demonstrated also the presence of PrP(c) in the nucleus of proliferating intestinal epithelial cells. Here we sought to decipher the function of this nuclear pool. In human intestinal cancer cells Caco-2/TC7 and SW480 and normal crypt-like HIEC-6 ce...
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